Origins and conversion
The tradition recorded in his life places Macarius's birth in Rome at the close of the fifteenth century, into a wealthy household that gave him an excellent education and raised him in piety. He is portrayed as a man who, rather than seeking honors or worldly position, turned his attention to the study of Scripture and the Church Fathers.
His life situates this period during the turmoil of the Protestant Reformation in the West. Troubled by the disputes within the Western Church, he is said to have concluded that the Orthodox Church preserved the faith he sought, and to have departed Rome secretly, journeying without funds and in poor clothing until he reached the region of Novgorod in northern Russia.