Historical Context
Domnina lived in the region of Cilicia in Asia Minor during a period of intense persecution of Christians under Roman authority. The sources situate her martyrdom in the reign of the emperor Diocletian, whose rule (284-305) coincided with severe measures against the Church.
She was imprisoned at Anazarbus, a city of Cilicia whose site corresponds to modern Anavarza (also identified with Aǧaçlı) in Adana Province, Turkey. She was accordingly counted among the saints of Roman Anatolia.